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Why CBD May Help Parkinson’s Disease Sufferers

Parkinson's Disease

Parkinson’s disease is a progressive nervous disorder which produces a negative effect on the movement of the limbs and muscles.

The symptoms of the disease start gradually and graduate into something with a barely noticeable tremor in one hand.

It is uncommon not to experience tremors in Parkinson’s disease, and they are often associated with stiffness or slow movements.

During the onset of the disease, it may show little or no expressions on the face, but the hands may face an inability to swing while working, speech may become slurred or soft.

The symptoms may worsen as the disease progresses over time.

There is little or no report on medications which can cure Parkinson’s disease; all the drugs administered are used to improve symptoms [1].

Managing the disease condition with medications have shown a considerable amount of success with a high level of side effects such as dry mouth, dizziness, drowsiness, blurred vision, vomiting, loss of appetite and heartburn.

The use of natural remedies such as CBD oils has shown a considerable amount of symptom improvement with little to no side effects.

How does CBD Help?

The active role of CBD and its high level of interaction with the endocannabinoid system (ECS) have been shown to modulate a wide range of physiological functions such as pain management and control, controlling appetite, motor control, mood and cognition [2-6].

The interaction between the GB1 and GB2 receptors of the ECS have been examined for its roles in pain, anorexia, spasticity, and chemotherapy-induced nausea [7] and results from this research has shown that CBD oil can play the following roles in Parkinson’s disease.

  1. Improved production of feel-good hormones

Parkinson’s disease is linked with dopamine depletion which translates into compromised motor functions after over 60-80% of the dopamine-producing neurons.

This can lead to the damage of the neurons and the inability of the brain to function correctly. When CBD interacts with the ECS receptors of the nervous system, it boosts the production of hormones such as dopamine thus improving muscular functions.

It also leads to improved nerve functions thus translating into the lesser symptoms associated with the stiffness of the limbs [2].

  1. Improved muscular health and movement:

Muscular health is determined by the ECS. It plays a key role in making sure that the cells are free from free radicals and are connected with the right nerves in the body. The use of CBD by Parkinson’s disease patients will improve their muscular health thus limiting the effects of the disease on the limbs.

  1. Reduced levels of pain and inflammation

Chronic pain usually occurs as a sign of inflammation or response to a disease condition in the body. It is controlled by the ECS, and a successful level of interaction between the GB1 and GB2 receptors of the ECS and CBD limits the rate of inflammation and above all, takes care of chronic pains.

People living with Parkinson disease can use CBD as an alternative to the over-the-counter painkillers in the market.

Final Thoughts

Note that CBD is not used as a treatment for Parkinson’s Disease but a remedy to reduce the symptoms experienced during the disease. 

You can buy high-quality, carefully curated CBD products online at the Ganjly CBD Marketplace. Here at the Ganjly CBD Marketplace, we’ve gathered together the best CBD products available from top US brands, so you can feel confident shopping our online store.


CITATIONS AND REFERENCES

  1. Parkinson’s Disease. https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/symptoms-causes/syc-20376055

  2. Di Marzo V, Melck D, Bisogno T, et al. Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action. Trends Neurosci. 1998;21:521–528 https://www.ncbi.nlm.nih.gov/pubmed/9881850.

  3. Howlett AC, Barth F, Bonner TI, et al. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev. 2002;54:161–202 https://www.ncbi.nlm.nih.gov/pubmed/12037135

  4. Di Marzo V. The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation. Pharmacol Res. 2009;60:77–84 https://www.ncbi.nlm.nih.gov/pubmed/19559360.

  5. Castillo PE, Younts TJ, Chavez AE, et al. Endocannabinoid signaling and synaptic function. Neuron. 2012;76:70–81. https://www.ncbi.nlm.nih.gov/pubmed/23040807

  6. Pacher P, Kunos G. Modulating the endocannabinoid system in human health and disease—successes and failures. FEBS J. 2013;280:1918–1943. https://www.ncbi.nlm.nih.gov/pubmed/23551849

  7. Husni AS, McCurdy CR, Radwan MM, et al. Evaluation of phytocannabinoids from high potency Cannabis sativa using in vitro bioassays to determine structure-activity relationships for cannabinoid receptor 1 and cannabinoid receptor 2. Med Chem Res. 2014;23:4295–4300 https://www.ncbi.nlm.nih.gov/pubmed/25419092

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